Probenecid, a gout remedy, inhibits pannexin 1 channels
نویسندگان
چکیده
منابع مشابه
Probenecid, a gout remedy, inhibits pannexin 1 channels.
Probenecid is a well-established drug for the treatment of gout and is thought to act on an organic anion transporter, thereby affecting uric acid excretion in the kidney by blocking urate reuptake. Probenecid also has been shown to affect ATP release, leading to the suggestion that ATP release involves an organic anion transporter. Other pharmacological evidence and the observation of dye upta...
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Normal myotubes and adult innervated skeletal myofibers express the glycoprotein pannexin1 (Panx1). Six of them form a "gap junction hemichannel-like" structure that connects the cytoplasm with the extracellular space; here they will be called Panx1 channels. These are poorly selective channels permeable to ions, small metabolic substrate, and signaling molecules. So far little is known about t...
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S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species. Therefore, we investigated whether Panx1 can be S-nitrosylated and whether this modification can affect channel activity. Using the biotin switch assay, we found that application of the...
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of a dissertation at the University of Miami. Dissertation supervised by Professor Gerhard Dahl. No. of pages in text. (89) The recently discovered pannexins represent a second family of gap junction proteins in vertebrates. However, instead of forming intercellular gap junction channels like connexins, pannexins operate as unpaired pannexons, allowing the flux of molecules between the cytoplas...
متن کاملNon-junction functions of pannexin-1 channels.
Pannexins are large-pore ion channels with broad expression in the central nervous system (CNS). The channels function by releasing large signaling molecules, such ATP and arachidonic acid derivatives, from neurons and possibly astrocytes. They might also contribute to novel forms of non-synaptic communication in the CNS, thereby affecting synaptic function, astrocytic Ca(2+) wave propagation a...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2008
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00227.2008